Beta-2 Microglobulin (B2M)

Catalogue Number: 126-12
Availability Discontinued, replaced with item 126-16
Product Name Beta-2 Microglobulin
Source Human Urine
Catalogue Number 126-12
Purity > 98% (SDS-PAGE)
Form Liquid
Protein 1.0 - 3.0 mg/mL (A280, E0.1%280nm=1.65)
Formulation Solution in 40 mM sodium phosphate, 150 mM sodium chloride, 1 mM EDTA, and 0.05% sodium azide, pH 7.2.
Appearance Clear, colorless to light straw colored liquid
Related Products GB2-80A - anti-Human B2M polyclonal antibody
126-11 - B2M antigen from human urine - Lyophilized
431-11 - Myoglobin antigen from human heart
Storage 2-8°C
Recertification 3 years
Infectious Disease Testing Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV, HBsAg, and syphilis by FDA approved methods.
Molecular Weight Approx. 12,000
Synonyms B2M, BMG, beta-2M
CAS Number 9066-69-7
UNSPSC code 51131907
Gene B2M, CDABP0092, HDCMA22P
Gene ID 567
Accession No P61769
References Anal. Chem., 2013, 85 (20), pp 9664–9670

Lee Biosolutions is the leading producer and supplier of human urine Beta-2 Microglobulin (B2M) for use in medical autoimmune research and manufacturing of clinical diagnostic assays.

Custom preparations, technical support, bulk quantities and aliquoting available, email for more details.

Serum beta-2 Microglobulin, an endogenous marker for renal function, has been shown to be an independent predictor of mortality in older adults.

The characteristics of B2M make it useful as a tumor marker for some blood cell cancers, for detecting kidney damage, and for distinguishing between glomerular and tubular disorders of the kidney. It is not diagnostic for a specific disease, but it gives the doctor additional information about someone's likely prognosis and about the health of their kidneys.

Human b-2 Microglobulin (B2MG) is an 11.8 kD protein identical to the light chain of the HLA-A, -B, and –C antigen. B2MG is expressed on nucleated cells, and is found at low levels in the serum and urine of normal individuals. B2MG concentrations are increased in inflammatory diseases, some viral diseases, renal dysfunction, and autoimmune diseases. A number of publications are available which explain the interpretation of serum levels in assessing the status of individuals with various clinical conditions.

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