Complement Component 3c (C3c)
Catalogue Number: 194-32
Description
| Product Name | Complement Component 3c |
| Source | Human Plasma |
| Catalogue Number | 194-32 |
| Purity | > 95% (SDS-PAGE) |
| Form | Lyophilized |
| Protein | Reported in mg/vial (A280 E0.1%=1.03) |
| Formulation | Lyophilized from phosphate buffered saline, pH 7.4. |
| Related Products | GC3-80A - anti-Human Complement C3 polyclonal antibody 194-31 - Complement C3c antigen from human plasma - Liquid 194-41 - Complement C4c antigen from human plasma |
| Storage | -20°C |
| Recertification | 4 years |
| Infectious Disease Testing | Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV, HBsAg, HIV-1 (NAT), HBV (NAT), HCV (NAT), and syphilis by FDA approved methods. |
| Product Details | Complement C3 is synthesized as a single chain of 185 kDa and is processed in the plasma to a disulfide-linked heterodimer consisting of an α-chain (115 kDa) and a β-chain (70 kDa). During complement activation, C3 is cleaved by C3 convertases to C3a (9 kDa) and C3b (176 kDa) comprised of the large C-terminal portion of the α-chain and the β-chain. Factor I further cleaves C3b into C3c (140 kDa), C3d (35 kDa), and C3g (7 kDa). The current protocol yields C3c, however intact C3 and/or C3a/C3b may be co-purified. |
| Molecular Weight | 138,000 |
| Synonyms | C3c |
| Gene | C3 |
| Gene ID | 718 |
| Gene Synonyms | AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1 |
Applications
Overview
Lee Biosolutions sells Human Complement C3 (C3) for research and diagnostic manufacturing.
Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
Human Complement proteins: It is thought that the complement system might play a role in many diseases with an immune component, such as Alzheimer's disease, asthma, lupus erythematosus, various forms of arthritis, autoimmune heart disease and multiple sclerosis.
Deficiencies of the terminal pathway predispose to both autoimmune disease and infections (particularly meningitis).
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