Apolipoprotein A1 (Apo A1)
| Product Name | Apolipoprotein A1 |
| Source | Human Plasma |
| Catalogue Number | 125-12 |
| Purity | > 95% (SDS-PAGE) |
| Form | Liquid |
| Formulation | Frozen in 10 mM ammonium bicarbonate, pH 7.4 |
| Storage | -70°C |
| Recertification | 1 year |
| Synonyms | ApoA1, APO A1 |
| Molecular Weight | 28,000 |
Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
Apo-AI comprises ~70% of the protein moiety in HDL. It is a single polypeptide chain consisting of 245 amino acids with glutamic acid as the C-terminal residue and aspartic acid as the N-terminal residue. The molecular mass is reported to be 28.3 kDa. The protein is made up of one major isoform (pI 5.6) and two minor isoforms (pI 5.53 and 5.46). Apo-AI shows a high content of a-helix structure.
The amphipathic regions in the á-helix structure seem to be responsible for lipid binding capacity. In aqueous solution, Apo-AI shows self-association with minor conformation change. Apo-AI activates lecithin-cholesterol (LCAT) acyltransferase, which is responsible for cholesterol esterification in plasma.
Apo-AI levels in normal plasma are 90-130 mg/dL. Apo-AI levels may be inversely related to the risk of coronary disease.
Lee Biosolutions, Inc
