Complement Component 4c (C4c)
Catalogue Number: 194-41
Description
| Product Name | Complement Component 4c |
| Source | Human Plasma |
| Catalogue Number | 194-41 |
| Purity | > 95% (SDS-PAGE) |
| Form | Liquid |
| Protein | 1.0 - 5.0 mg/mL (E0.1%280nm = 0.92) |
| Identity | Confirmed by Western Blot |
| Formulation | 0.2 micron filtered frozen solution in phosphate buffered saline, pH 7.4. |
| Related Products | GC4-80A - anti-Human Complement C4 polyclonal antibody 194-42 - Complement C4c antigen from human plasma - Lyophilized 194-31 - Complement C3c antigen from human plasma |
| Storage | -20°C |
| Recertification | 2 years |
| Infectious Disease Testing | Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV, HBsAg, HIV-1 (NAT), HBV (NAT), HCV (NAT), and syphilis by FDA approved methods. |
| Product Details | Complement C4 (200 kDa) is composed of three polypeptide chains – α (93 kDa), β (78 kDa), and γ (33 kDa). During complement activation, C4 is cleaved by the serine protease C1s to C4a (9 kDa) and C4b (190 kDa). C4b is further cleaved by factor I to C4d (45 kDa) and C4c (140 kDa). The current protocol yields C4c, however intact C4 and/or C4b and C4d may be co-purified. |
| Synonyms | C4, Complement C4, C4c |
| Molecular Weight | 147,000 |
| Gene | C4A, C4B |
| Gene Synonyms | DAMC-258G8.6, C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG, DADB-112B14.11-001, C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4F, CH, CO4, CPAMD3 |
| Gene ID | 720, 721 |
Applications
Overview
Lee Biosolutions sells Human Complement C4c (C4c) for research and diagnostic manufacturing.
Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
Human Complement proteins: It is thought that the complement system might play a role in many diseases with an immune component, such as Alzheimer's disease, asthma, lupus erythematosus, various forms of arthritis, autoimmune heart disease and multiple sclerosis.
Deficiencies of the terminal pathway predispose to both autoimmune disease and infections (particularly meningitis).
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