Troponin I (sTnI)

Catalogue Number: 550-13
Availability Discontinued
Product Name Troponin I antigen
Source Human Skeletal Muscle
Catalogue Number 550-13
Purity > 98% (SDS-PAGE)
Purity Note Contains a mixture of slow (22 kDa) and fast (21 kDa) isoforms.
Form Liquid
Protein > 0.5 mg/mL (Coomassie)
Formulation Solution in 8 M urea, 100 mM sodium chloride, 50 mM Tris-HCl, 15 mM β-mercaptoethanol, 2 mM EDTA, pH 7.4.
Related Products 550-21 - Troponin T from human heart
431-11 - Myoglobin from human heart
426-10 - Myeloperoxidase from human leukocytes
Storage -20°C
Recertification 2 years
Infectious Disease Testing Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV and HBsAg by FDA approved methods.
Synonyms Tn-I, muscle Tn-I, TnI, sTnI, sTn-I
Molecular Weight ~21,000
CAS Number 77108-40-8

Lee Biosolutions produces Human Skeletal Muscle Troponin I (Tn-I) for research and manufacturing uses.

Custom preparations, technical support, bulk quantities and aliquoting available, email for more details.

Troponin I (TnI) is one of three subunits that form the troponin complex of the thin filaments of striated muscle. The troponin complex serves as a calcium-sensitive switch that regulates striated muscle contraction. Troponin I binds actin and inhibits actomyosin ATPase activity in the absence of calcium. Skeletal muscle troponin I exists in two isoforms, TnI-fast and TnI-slow, expressed respectively in fast and slow-twitch muscle fibers. The two isoforms are characterized by molecular weights ~ 21 kDa (fast) and 22 kDa (slow). The ratios of slow and fast isoforms vary with muscle source and species.

Human Troponin is a family of proteins (I, T, C) found in skeletal and heart muscle fibers; cardiac troponin helps muscles contract. Certain subtypes of human troponin (cardiac troponin I and troponin T) are very sensitive and specific indicators of damage to the heart muscle myocardium). Human Troponins are measured in the blood to differentiate between unstable angina and myocardial infarction (heart attack) in patients with chest pain. A patient who had suffered from a myocardial infarction would have an area of damaged heart muscle and so would have elevated cardiac troponin levels in the blood.

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