Complement Component 4c (C4c)
| Product Name | Complement Component 4c |
| Source | Human Plasma |
| Catalogue Number | 194-42 |
| Purity | > 95% (SDS-PAGE) |
| Form | Lyophilized |
| Protein | Reported in mg/vial (E0.1%280nm = 0.92) |
| Identity | Confirmed by Western Blot |
| Formulation | Lyophilized from phosphate buffered saline, pH 7.4. |
| Related Products | GC4-80A - anti-Human C4 polyclonal antibody 194-41 - C4 antigen from human plasma - Liquid 194-31 - C3 antigen from human plasma |
| Storage | -20°C |
| Recertification | 3 years |
| Infectious Disease Testing | Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV, HBsAg, HIV-1 (NAT), HBV (NAT), HCV (NAT), and syphilis by FDA approved methods. |
| Product Details | Complement C4 (200 kDa) is composed of three polypeptide chains – α (93 kDa), β (78 kDa), and γ (33 kDa). During complement activation, C4 is cleaved by the serine protease C1s to C4a (9 kDa) and C4b (190 kDa). C4b is further cleaved by factor I to C4d (45 kDa) and C4c (140 kDa). The current protocol yields C4c, however intact C4 and/or C4b and C4d may be co-purified. |
| Synonyms | C4, Complement C4, C4c |
| Gene | C4A, C4B |
| Gene Synonyms | DAMC-258G8.6, C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG, DADB-112B14.11-001, C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4F, CH, CO4, CPAMD3 |
| Gene ID | 720, 721 |
Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
It is thought that the complement system might play a role in many diseases with an immune component, such as Alzheimer's disease, asthma, lupus erythematosus, various forms of arthritis, autoimmune heart disease and multiple sclerosis.
Deficiencies of the terminal pathway predispose to both autoimmune disease and infections (particularly meningitis)
Human Complement C4c is used as an immunogen and our product is an inactive form.
C4c is produced in Human plasma having a molecular mass of 210 kDa. It interacts with complement C1 and complemenet C2 to form complement C3 convertase of the classic activation pathway. Systemic lupus erythematosus is often associated with congenital complemnet C4 deficiency. Reduced levels of components of the classic pathway complement(s)(C1, C2, C4, C3) are common after such activation, Systemic lupus erythematosus , acute serum sickness and conditions associated with circulating immune complexes.
Lee Biosolutions, Inc
