Brain Natriuretic Peptide-32 (BNP-32)
| Product Name | Brain Natriutetic Peptide 32 |
| Source | Synthetic |
| Source Note | Human Sequence |
| Catalogue Number | 129-10 |
| Purity | > 95% (HPLC) |
| Form | Lyophilized |
| Assay | > 65% (Elemental Analysis) |
| Appearance | White lyophilisate |
| Solubility | Clear and colorless in 1 mg/mL water |
| Related Products | 129-15 - NT-ProBNP antigen 991-24-S-NTPBNP - NT-ProBNP serum samples from human patients |
| Storage | -20°C |
| Synonyms | BNP-32, Nesiritide, B-type natriuretic peptide, GC-B |
| Formula | C143H244N50O42S4 |
| Molecular Mass | 3464.09 |
| CAS Number | 114471-18-0 |
Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
Human Brain Natriuretic Peptide BNP-32 also known as B-type natriuretic peptide or GC-B has a Peptide Sequence: H-Ser-Pro-Lys-Met-Val-Gin-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-lle-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH (disulfide bond).
Brain Natriuretic Peptide (BNP-32) is a 32-amino-acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of myocytes (heart muscles cells) in the ventricles. At the time of release, a co-secreted 76 amino acid n-terminal fragment (NT-proBNP) is also released with B-type natriuretic peptide. B-type natriuretic peptide BNP binds to and activates NPRA in a similar fashion to atrial natriuretic peptide but with 10-fold lower affinity. The biological half-life of BNP however, is twice as long as that of ANP. Both ANP and BNP have limited ability to bind and activate NPRB.
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