Myosin Light Chain (MLC)

Catalogue Number: 428-11
Availability Discontinued
Product Name Myosin Light Chain
Source Human Heart
Catalogue Number 428-11
Purity > 95% (SDS-PAGE)
Form Lyophilized
Protein 1 mg protein/mg solid (A280, E0.1%=0.211)
Form Lyophilized from ammonium bicarbonate
Reconstitution Neutral pH buffer of choice. Avoid extreme high and low pH
Recertification 5 years
Storage -20°C
Synonyms MLC, MYL3_Human
Molecular Weight ~20,000

Lee Biosolutions sells human heart Myosin Light Chain (MLC) for research, life science and diagnostic manufacturing uses.

Custom preparations, technical support, bulk quantities and aliquoting available, email for more details.

These enzymes are important in the mechanism of contraction in muscle. Once there is an influx of calcium cations (Ca++) into the muscle, either from the sarcoplasmic reticulum or, more importantly, from the extracellular space, contraction of smooth muscle fibers may begin. First, the calcium will bind to calmodulin. This binding will activate MLCK, which will go on to phosphorylate the myosin light chain at serine residue 19. This will enable the myosin crossbridge to bind to the actin filament and allow contraction to begin (through the crossbridge cycle). Since smooth muscle does not contain a troponin complex like striated muscle does, this mechanism is the main pathway for regulating smooth muscle contraction

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