Troponin I (cTnI)
| Product Name | Troponin I antigen |
| Source | Human Heart |
| Catalogue Number | 550-11 |
| Purity | > 98% (SDS-PAGE) |
| Form | Liquid |
| Protein | > 0.5 mg/mL (A280, E0.1%=0.42) |
| Formulation | Solution in Urea, Tris-HCl, beta-mercaptoethanol, EDTA, pH 7.3-7.5. |
| Related Products | 550-21 - Troponin T from human heart 431-11 - Myoglobin from human heart 426-10 - Myeloperoxidase from human leukocytes |
| Storage | -20°C |
| Recertification | 2 years |
| Infectious Disease Testing | Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV, HBsAg, HCV NAT, and HIV-1 NAT by FDA approved methods. |
| Synonyms | Tn-I, hTn-I, cTnI, cardiac Tn-I, TnI |
| Molecular Weight | ~24,000 |
| CAS Number | 77108-40-8 |
Lee Biosolutions produces Human Heart Troponin I (Tn-I) for research and manufacturing uses.
Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
Current studies show that Troponin I is a part of the troponin complex. Troponin I binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. Human Troponin is a family of proteins (Troponin I, T and C) found in skeletal and heart muscle fibers; cardiac Troponin helps muscles contract. Certain subtypes of human troponin (cardiac troponin I and T) are very sensitive and specific indicators of damage to the heart muscle myocardium).
Lee Biosolutions, Inc
