Myeloperoxidase (MPO) Antigen
| Product Name | Myeloperoxidase |
| Source | Human Neutrophils |
| Catalogue Number | 426-10 |
| Purity | > 96% (SDS-PAGE) |
| Form | Liquid |
| Protein | 1.0 - 2.0 mg/mL (A430, E0.1%=1.19) |
| Activity | > 1,000 U/mL |
| Unit Definition | One unit of Myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of ¼ micromole of tetraguaiacol per minute at pH 7.0 and 25°C. |
| Specific Activity | > 1,000 U/mg protein |
| Appearance | Clear, greenish Liquid |
| Formulation | 0.2 um solution in 50 mM sodium acetate, 100 mM sodium chloride, pH 6.0, with bromo-nitro-dioxane and methylisothiazolone as preservatives. |
| Related Products | 550-21 - Troponin T antigen from human heart 550-11 - Troponin I antigen from human heart 431-11 - Myoglobin antigen from human heart |
| Storage | 2-8°C |
| Recertification | 2 years |
| Infectious Disease Testing | Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV, HBsAg, HCV NAT, HIV-1 NAT and syphilis by FDA approved methods. |
| Synonyms | MPO, pANCA |
| CAS Number | 9003-99-0 |
| E.C. Number | 1.11.2.2 |
| Gene ID | 4353 |
| Accession No | P05164 |
| References | 1) J. Am. Chem. Soc. 132, 1, 168-177 2) Pulli B, Ali M, Forghani R, Schob S, Hsieh KLC, Wojtkiewicz G, et al. (2013) 3) Free Radical Biology and Medicine, Volume 60, July 2013, Pages 98-106 4) Radiology: Volume 263: Number 2—May 2012, Pages 451-460 |
Lee Biosolutions is the largest primary manufacturer of Myeloperoxidase (MPO) enzymes for medical research and diagnostic manufacturing globally.
Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
Rz is an abbreviation for Reinheitszahl (purity number). It is the ratio of absorbance at 430 nm (heme)/ 280 nm (total protein). It is a measure of the purity of the enzyme, with any value above 0.8 being highly pure.
MPO is a peroxidase enzyme occurs the most in neutrophil granulocytes (a subtype of white blood cells). It is a lysosomal protein stored in azurophilic granules of the neutrophil. Myeloperoxidase has a green heme pigment and is found in pus and some forms of mucus. It is recognized as an important factor in many inflammatory diseases such as cardiovascular and neurological diseases. MPO-specific imaging agents would thus be highly useful to diagnose early disease, monitor disease progression, and quantify treatment effects.
Lee Biosolutions, Inc
