Low Density Lipoprotein (LDL)
| Product Name | Low Density Lipoprotein |
| Source | Human Plasma |
| Catalogue Number | 360-10 |
| Form | Liquid |
| Purity | Plasma Fraction |
| Total Cholesterol | > 4,000 mg/dL (Enzymatic) Inquire for custom concentrations and cholesterol ratios |
| Triglyceride | Report in mg/dL |
| Triglyceride Ratio | < 0.9 (Triglycerides/Total Cholesterol) |
| Electrophoresis | One major band observed, corresponds to LDL (Helena QuickGel® Cholesterol) |
| Appearance | Yellow to orange liquid |
| Preservatives | None, EDTA free |
| Handling | - Thaw quickly, in a 37°C water bath, removing as soon as thawed. - Store at 2 – 8°C for up to one week, -20°C for up to three months, and up to 24 months at -70°C. - Dilute with 0.15 M sodium chloride. |
| Related Products | 361-10 - HDL Concentrate from human plasma 185-10 - Cholesterol Concentrate from bovine serum 361-56 - Triglyceride Concentrate from human plasma |
| Recertification | 2 years |
| Storage | -20°C (up to three months) -70°C (more than three months) |
| Infectious Disease Testing | Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV, HBsAg, HIV-1 (NAT), HBV (NAT), HCV (NAT), and syphilis by FDA approved methods. |
| Molecular Weight | 2.75 million (ref. Tetz second Edition) |
| Synonyms | LDL, LDL-C, Beta-Lipoprotein, Concentrate, Fraction |
| Country of Origin | United States |
| Application Note | Stable in liquid and lyophilized controls, calibrators and standards. |
| References | The Journal of Lipid Research, November 2013, 54, 3016-3029. Acta Biomaterialia Volume 71, 15 April 2018, Pages 420-431 |
Lee Biosolutions is world leader in the manufacturing of human plasma Low Density Lipoprotein (LDL) and other cholesterol/triglyceride products for research and in vitro diagnostic (IVD) manufacturing uses.
Custom LDL/HDL and triglyceride ratios, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
OVERVIEW
Low-density lipoprotein (LDL), often deemed the “bad cholesterol”, is a lipoprotein that carries cholesterol throughout the body via blood circulation. Due to its role in dispositioning cholesterol TO tissues and organs of the body, having high levels of LDL can lead to plaque formation in the arteries, possibly increasing the risk of heart disease and stroke.
It is recommended by the National Heart, Lung, and Blood Institute to maintain a LDL cholesterol level lower than 100 mg/dL, optimally.
APPLICATIONS
Diagnostic – Clinical calibration control
Source of antigens for developing antibodies
Cholesterol Research in regards to pharmaceutical drug development and familial hypercholesterolaemia
Developing new methods of LDL measurement
EMERGING RESEARCH
LDL size has been shown to be linked to cardiovascular health. The larger the LDL particles, the greater correlation to a cardiovascular event.
Lowering LDL to the levels of a new-born baby has been shown to dramatically decrease the risk of heart disease.
Direct homogeneous assays rather than determining LDL-C values based on the Friedewald calculation may improve lipoprotein analyses and allow for a more accurate LDL value, especially in regards to patients suffering from hyperlipidemia
Lee Biosolutions, Inc
